Deca Durabolin

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Dec-Durabolins.com is a subweb of the parent website UK Steroids which deals mostly with anabolics in the UK. This website provides information on Nandrolone Decanoate as manufactured by Organon Pakistan and Norma Greece. Also provided is information to bodybuilders using this particular anabolic steroid.


Chemical Name: Estr-4-en-3-one, 17-((1-oxodecyl)oxy)-, (17beta)

What does the manufacturer Organon say?

Composition

Each ml of the oily solution contains 100mg nandrolone decanoate B.P.           

Characteristics

Action: Deca-Durabolin"100" is a high dosage form of  nandrolone decanoate designed especially for adjuvant therapy in the treatment of certain blood disorders. Nandrolone the pharmacologically active substance of the preparation, is chemically related to the male hormone. Compared to testosterone, it has an enhanced anabolic and reduced androgenic activity. This has been demonstrated in animal bioassays and explained by receptor binding studies. The low androgenicity of nandrolone is confirmed in clinical use.

In animals, nandrolone decanoate possesses an erythropiesis-stimulating effect probably by directly stimulating the haematopoietic stem cells in the bone marrow and by increasing the release of erythropoietin. It also affords protection against bone marrow depression caused by cytotoxic agents. In the human, Deca-Durabolin "100"  stimulates erythropoiesis as demonstrated by rises in the red blood cell mass, and in the haemoglobin and haematocrit values. This effect is utilized therapeutically in the treatment of anaemia due to a decreased production of erythropoietin, bone marrow depression induced by chemotherapy, or hypoplasia of the stem cells in the bone marrow. In the latter condition (e.g. aplastic anaemia) the erythropoietic response is frequently accompanied by a positive on leucopoiesis and thrombopoises. Androgenic effects (e.g. virilisation) are relatively uncommon at the recommended dosages. Nandrolone lacks the C17 alpha-alkyl group which is associated with the occurrence of liver dysfunction and cholestatsis.

Pharmacokinetics

Nandrolone decanoate is slowly released from the injection site into the blood with a half life of 6 days. In the blood the ester is rapidly hydrolysed to nandrolone with a half life of  one hour or less. The half life for the combined process of hydrolysis of nandrolone decanoate and of distribution and elimination of nandrolone is 4-3 hours. Nandrolone is metabolized by the liver, 19-norepiandrosterone have been identified as metabolites in the urine. It is not known whether these metabolites display a pharmacological action.

Indication                                                 Dosage
Anaemia of chronic renal failure                  Males: 200mg every week, Females:100mg every week
Aplastic Anaemia                                      50-150mg every week
Anaemia due to cytotoxic therapy   200mg every week, starting 2 weeks prior to the course of cytotoxic therapy. This treatment should be continued throughout cytotoxic therapy and thereafter during the recovery period until the blood count has returned to normal.

N.B:- 

  • Treatment with Deca-Durabolin "100"  does not substitute for other therapeutic measures.
  • The onset of a therapeutic effect may vary widely among patients. If no satisfactory response occurs after 3-6 months of treatment administration should be discontinued.
  • After a satisfactory improvement or a normalisation of the red blood picture has been obtained, treatment should be withdrawn gradually on the basis of regular monitoring of the haematological parameters. Should a relapse occur at any time whilst the dose is being reduced, or after stopping the treatment, re-institution of therapy should be considered.
  • A dosage scheme for children cannot be given because of insufficient clinical experience.

Administration      

Deca-Durabolin"100" should be administered by deep intramuscular injection.

Contra-indications

  • Pregnancy
  • Known or suspected carcinoma of the prostate or breast in the male

Use during pregnancy and breast-feeding

this medicine is contraindicated during pregnancy because of possible masculinization of the foetus. There are insufficient data on the use of the medicine during breastfeeding to assess potential harm to the infant or a possible influence on milk production.

Warnings and precautions

-The recommended dosage should not be exceeded

-If signs of virilisation develop, discontinuation of  the treatment should be considered, preferably in consultation with the patient.

-It is recommended to monitor patients with any of the following conditions:

  • Latent or overt cardiac failure, renal dysfunction, hypertension or migraine (or a history of these conditions), since anabolic steroids may occasionally induce fluid retention:
  • Incomplete statural growth, since anabolic steroids in high dosages may accelerate epiphyseal closure:
  • Skeletal metastestes of breast carcinoma. In these patients hypercalcaemia may develop both spontaneously  and as a result of anabolic steroid therapy. The latter can be indiciative of a positive tumour response to the hormonal treatment. Nevertheless, the hypercalcaemia should first be treated properly and after restoration of normal calcium levels, hormone therapy can be resumed.
  • Liver dysfunction
  • The use of anabolic steroids to enhance athletic ability may carry severe risks to the users health and should be discouraged.

Interactions

Anabolic Steroids may improve glucose tolerance and decrease the need for insulin or other antidiabetic medicines in diabetes.

Although only one possible case of interaction with an oral anticoagulant has been observed, it is advisable to check the prothrombin time regularly when Deca-Durabolin"100" is used in patients on anticoagulant therapy.

Adverse reactions

The high dosages, which are required to obtain a therapeutic effect in the indications may cause:

  • Virilisation which appears in sensitive women as hoarseness, acne, hirsutism and increase of libido; in prepubertal boys as an increase in the frquency of erections and phallic enlargement, and in girls as an increase of pubic hair and clitoral hypertrophy. Hoarsness may be the first symptom of vocal change which may end in a long-lasting, sometimes irreversible deepening of the voice.
  • Amenorrhoea.
  • Inhibition of spermatogenesis.
  • Premature epiphyseal closure
  • Fluid retention
  • Occasional, abnormal values in some liver function tests. These changes appear to be reversible after completion of treatment of the course.

Overdosage

The acute toxicity of nandrolone decanoate in animals is very low. There are no reports of acute overdosage with Deca-Durabolin"100" in the human.

Storage

Keep in a dry place between 2-30C away from light.

Info For Bodybuilders

Deca Durabolin is the brand name for nandrolone decanoate. World wide Deca is one of the most popular injectable steroids. It's popularity is likely due to the fact that Deca exhibits significant anabolic effects with minimal androgenic side effects. Considered by many the best overall steroid for a man to use (side effects vs. results) Deca is most commonly injected once per week at a dosage of 200-400mg. With this amount, estrogen conversion is slight so gyno is usually not a problem. Also uncommon are problems with liver enzymes, blood pressure or cholesterol levels. At higher dosages, side effects may become increasingly more frequent, but this is still a very well tolerated drug.

 For bodybuilding, Deca can effectively be incorporated in both mass and cutting cycles. One major drawback to Deca is that it can be detected in a drug screen for as long as a year after use. Deca durabolin is considered to be the most popular of all steroids. It is an oil based injectable that comes in 100 mg/cc containers. It produces very few side effects. Deca durabolin is easy on the liver and promotes good size and strength gains while reducing body fat. Deca only aromatizes (converts to estrogen) in extreme dosages. It is highly anabolic but only moderately androgenic. Deca durabolin does shut down natural testosterone production, but it is not extreme. Gains will minimally dissipate, if at all, after the cycling period if workouts are kept intense. Usual dose is 200 mg per week with highs ranging 200 mg a day. The average duration is about 2 to 4 month.

There are very few side effects. Blood clotting time is increased so that some people may experience bloody noses when they are dehydrated. Deca durabolin is generally considered by athletes and sports medicine physicians to be the safest and most effective injectable anabolic steroid. Nandrolone decanoate is mildly androgenic and is becoming increasingly popular with women bodybuilders. Although side effects similar to those of other steroids have been reported, the effects are relatively uncommon when compared to other forms of steroids. Nandrolone does not effect the immune system, unlike testosterone! It will not damage connective tissue, i.e. elbows, knees (Big problem amongst heavy steroid users). It does not aromatize easily and gives the body a lean hard look.

 

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